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According to the research team leader Prue Talbot, professor in the Department of Molecular, Cell and Systems Biology at the University of California, Riverside: “We found some flavor chemicals, such as ethyl maltol, also correlate with cytotoxicity, but nicotine seems to be the most potent chemical in Juul products, due to it very high concentration.” Although federal regulations limit the sales of Juul products to individuals 21 years and older, Juuling still remains prominent among adolescents, primarily middle-school and high-school-aged youth

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By early 2020, the CDC determined that vitamin E acetate was “strongly linked” to the EVALI outbreak